Report on the use of Lion’s mane mushroom supplements to alleviate depression

Depression is a common mental health disorder that affects millions of people worldwide. It is characterized by feelings of sadness, hopelessness, and a loss of interest in activities that were once enjoyed. The current standard of care for depression includes therapy and pharmacotherapy, but some individuals may prefer to use natural supplements as an adjunct or alternative treatment. Lion’s mane mushroom (Hericium erinaceus) is a beneficial mushroom that has been used for centuries in traditional Chinese medicine to improve brain function and overall health. In recent years, there has been growing interest from the west in the potential use of Lion’s mane mushroom as a natural remedy for depression.

The exact mechanism by which Lion’s mane mushroom may alleviate depression is not yet fully understood. However, the bioactive compounds present in the mushroom, such as hericystin and erinacine, have been shown to have neuroprotective effects. They may also promote the growth and repair of nerve cells, potentially leading to improved brain function and reduced symptoms of depression. Additionally, some preliminary studies have suggested that Lion’s mane mushroom may have an impact on neurotransmitters such as serotonin, which play a crucial role in regulating mood.

Although the clinical evidence for the use of Lion’s mane mushroom as a treatment for depression is still limited, there have been several studies that have explored its potential benefits. A randomized, double-blind, placebo-controlled study conducted in Japan found that consumption of Lion’s mane mushroom for four weeks improved symptoms of depression and anxiety in individuals with mild cognitive impairment. In another study, a daily dose of Lion’s mane extract was found to significantly improve symptoms of depression, as well as cognitive function, in post-menopausal women.

A systematic review of the available literature on the use of Lion’s mane mushroom for depression found that the current evidence is limited but suggests that it may have potential as a complementary or alternative treatment for depression. However, the authors of the review also noted that further well-designed studies are needed to confirm these findings.

Lion’s mane mushroom is generally considered safe when consumed in normal food amounts. However, there have been limited reports of side effects, including upset stomach and allergic reactions. As with any dietary supplement, it is important to speak with a healthcare provider before taking Lion’s mane mushroom to ensure it is safe and appropriate for an individual’s specific needs and health status.

In conclusion, while the clinical evidence for the use of Lion’s mane mushroom as a treatment for depression is limited, the available studies suggest that it may have potential benefits. However, more well-designed studies are needed to confirm these findings and further research is required to determine the optimal dose and formulation for use as a therapeutic agent.


Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372.